✅ Parasite Cleanse kit includes

1. Albendazole + Ivermectin (Bandy Plus 12) – 30 tablets
2. Praziquantel 600 mg (Biltree 600) – 50 tablets
3. Fluconazole 400 mg – 10 tablets
4. Tinidazole 500 mg – 40 tablets

It eradicate roundworms, pinworms, tapeworms, flukes, protozoa, candida etc.

---

🩺 MECHANISM OF ACTION OF EACH MEDICATION

---

1️⃣ Albendazole + Ivermectin (Bandy Plus 12)

✔ Albendazole – Mechanism of Action

Albendazole is a broad-spectrum antiparasitic acting on nematodes (roundworms) and some tapeworms.

Mechanism:

• Binds to parasitic β-tubulin, preventing microtubule polymerization
• Inhibits glucose uptake → parasite loses energy
• Leads to immobilization, paralysis, and death

Effective against:
Roundworms, hookworms, pinworms, whipworms, some tapeworm species, hydatid disease, neurocysticercosis (under supervision).

---

✔ Ivermectin – Mechanism of Action

Ivermectin targets nematodes and some ectoparasites.

Mechanism:

• Binds to glutamate-gated chloride channels in parasite nerve & muscle cells
• Causes massive chloride influx → flaccid paralysis
• Parasite loses ability to feed → dies or is expelled

Effective against:
Strongyloides, onchocerca, some roundworms, scabies, lice.

---

2️⃣ Praziquantel 600 mg

Primarily used for tapeworms and flukes (trematodes).

✔ Mechanism of Action

• Increases calcium permeability in tegument & muscles of the parasite
• Causes spastic paralysis
• Damages parasite surface → immune system can attack
• Leads to dislodgement and death

Effective against:
Tapeworms (Taenia, Diphyllobothrium), schistosomiasis, liver flukes, lung flukes.

---

3️⃣ Fluconazole 400 mg

This is antifungal use for Candida and other fungal infections.

✔ Mechanism of Action

• Inhibits fungal CYP450 enzyme lanosterol 14-α-demethylase
• Blocks conversion of lanosterol → ergosterol
• Without ergosterol, fungal cell membranes become unstable
• Leads to fungal cell death or growth inhibition

Effective against:
Candida (yeast infections), cryptococcus, some dermatophytes.

---

4️⃣ Tinidazole 500 mg

Tinidazole is an antiprotozoal and anti-anaerobic antibiotic.

✔ Mechanism of Action

• Enters anaerobic protozoa (Giardia, Entamoeba, Trichomonas)
• Activated inside the organism → creates cytotoxic radicals
• Radicals damage DNA → cell death

Effective against:
Giardia, amoebiasis, trichomoniasis, some anaerobic bacteria.